Paul L. Kaufman, M.D.
Professor and Chair
2870 University Avenue, Suite 102
Madison, WI 53705-3611
Office : (608) 263-9797
Clinic : (608) 263-7171
| Degrees: | M.D. 1967, New York School of Medicine, NY |
| Appointments: | Wisconsin Regional Primate Research Center, Animal Health and Biomedical Sciences - School of Veterinary Medicine, Director-Glaucoma Services |
| Internships: | Bellevue Hospital, New York, NY |
| Residency: | Washington University School of Medicine and Barnes Hospital, St. Louis, MO |
| Fellowships: | Ocular Pharmacology Fellowship, Seeing Eye and National Institutes of Health Research Fellow, Departments of Pharmacology and Physiology, University of Uppsalla, Uppsala, Sweden |
| Research: | My research centers on studies of the physiology, pharmacology, morphology, cell biology, genetic manipulation, neural control, biomechanics and aging of the aqueous humor formation and drainage and accommodative mechanisms in the non-human primate, seeking to understand the pathophysiology and develop new therapies for the human diseases of glaucoma and presbyopia. Glaucoma is the second most common cause of irreversible visual loss in adult Americans, the most common among African Americans, and the most common world-wide, while presbyopia is the most common of all ocular afflictions. |
| Publications: | Mattison JA, Croft MA, Dahl DB, Roth GS, Lane MA, Ingram DK, Kaufman PL. Accommodative function in rhesus monkeys: effects of aging and calorie restriction Age: J Am Aging Assoc 27: 59-67, 2005. Gabelt BT, Okka M, Dean TR, Kaufman PL. Aqueous humor dynamics in monkeys after topical R-DOI. Invest Ophthalmol Vis Sci, 46:4691-4694, 2005. Hashimoto K, Parker A, Malone P, Gabelt BT, Rasmussen C, Kaufman PL, Hernandez MR. Long-term activation of c-Fos and c-Jun in optic nerve head astrocytes in experimental ocular hypertension in monkeys and after exposure to elevated pressure in vitro. Brain Res. 1054(2):103-15, 2005. Liu X, Hu Y, Filla MS, Gabelt BT, Peters DM, Brandt CR, Kaufman PL. The effects of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes. Mol Vis. 11:1112-1121, 2005. Kiland JA, Gabelt BT, Kaufman PL. Effect of age on outflow resistance washout during anterior chamber perfusion in rhesus and cynomolgus monkeys. Exp Eye Res, 81:724-730, 2005. Kim CBY, VerHoeve JN, Kaufman PL, Nork TM. Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeys. Doc Ophthalmologica 111:113-125, 2005. Sabanay I, Tian B, Gabelt BT, Geiger B, Kaufman PL. Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys. Exp Eye Res, 82:236-246, 2006. Croft MA, Glasser A, Heatley G, McDonald J, Ebbert T, Nadkarni NV, Kaufman PL. The zonula, lens and circumlental space in the normal iridectomized rhesus monkey eye. Invest Ophthalmol Vis Sci 47:1087-1095, 2006. Croft MA, Glasser A, Heatley G, McDonald J, Ebbert T, Dahl DB,Nadkarni, NV, Kaufman PL. Accommodative ciliary body and lens function in rhesus monkeys. I. Normal lens, zonule and ciliary process configuration in the iridectomized eye. Invest Ophthalmol Vis Sci,. 47:1076-1086, 2006. Filla MS, Kaufman PL, Woods A, Peters DMP. b1 and b 3 integrins cooperate to induce a unique syndecan-4 containing cross-linked actin networks (CLANS) in human trabecular meshwork (HTM) cells. Invest Ophthalmol Vis Sci 47:1956-1967, 2006 Gabelt BT, Hu Y, Vittitow JL, Rasmussen CA, Grosheva I, Bershadsky AD, Geiger B, Borrás T, Kaufman PL. Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments. Exp Eye Res, 82:935-944, 2006. Grosheva I, Vittitow JL, Goichberg I, Borrás T, Kaufman PL, Geiger B, Bershadsky AD. Caldesmon effects on the actin cytoskeleton and cell adhesion in cultured HTM cells. Exp Eye Res 82:945-958, 2006 Agapova OA, Kaufman PL, Hernandez MR. Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma Exp Eye Res 82:1053-1059, 2006 May CA, Gottanka J, Kaufman PL, Lütjen-Drecoll E, Scholz M. Choroidal innervation and optic neuropathy in macacque monkeys with laser- or anterior chamber perfusion-induced short-term elevation of intraocular pressure. Exp Eye Res 82:1060-1067, 2006 Hu Y, Gabelt BT, Kaufman PL. Monkey organ-cultured anterior segments; technique and response to H-7. Exp Eye Res 82:1100-1108, 2006. |