Cruickshanks Lab // Publications // Aug 15 2019

PubMed ID: 31412233

Author(s): Braffett BH, Lorenzi GM, Cowie CC, Gao X, Bainbridge KE, Cruickshanks KJ, Kramer JR, Gubitosi-Klug RA, Larkin ME, Barnie A, Lachin JM, Schade DS; DCCT/EDIC Research Group. RISK FACTORS FOR HEARING IMPAIRMENT IN TYPE 1 DIABETES. Endocr Pract. 2019 Aug 14. doi: 10.4158/EP-2019-0193. [Epub ahead of print]

Journal: Endocrine Practice : Official Journal Of The American College Of Endocrinology And The American Association Of Clinical Endocrinologists, Aug 2019

Objective: Studies have demonstrated that HbA1c is a significant predictor of hearing impairment in type 1 diabetes. We identified additional factors associated with hearing impairment in participants with type 1 diabetes from the Diabetes Control and Complications Trial and its observational follow-up, Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. Methods: 1,150 DCCT/EDIC participants were recruited for the Hearing Study. A medical history, physical measurements, and a self-administered hearing questionnaire were obtained. Audiometry was performed by study-certified personnel and assessed centrally. Logistic regression models assessed the association of risk factors and comorbidities with speech- and high-frequency hearing impairment. Results: Mean age was 55±7 years, duration of diabetes 34±5 years, and DCCT/EDIC HbA1c 7.9±0.9%. In multivariable models, higher odds of speech-frequency impairment were significantly associated with older age, higher HbA1c, history of noise exposure, male sex, and higher triglycerides. Higher odds of high-frequency impairment were associated with older age, male sex, history of noise exposure, higher skin intrinsic florescence (SIF) as a marker of tissue glycation, higher HbA1c, non-professional/non-technical occupations, sedentary activity, and lower LDL cholesterol. Among participants who previously completed computed tomography and carotid ultrasonography, coronary artery calcification (CAC)>0 and carotid intima-medial thickness were significantly associated with high- but not speech-frequency impairment. Conclusion: Consistent with previous reports, male sex, age, several metabolic factors, and noise exposure are independently associated with hearing impairment. The association with SIF further emphasizes the importance of glycemia, as a modifiable risk factor, over time. In addition, the macrovascular contribution of CAC is novel and important. Clinical Trials Registration Numbers: NCT00360893, NCT00360815.