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George Kambara, MD, Vision Science Symposium

March 16, 2018 @ 8:00 am - 4:00 pm

2017 Kambara Symposium

Presented by the UW Department of Ophthalmology and Visual Sciences

Keynote Speaker: Abbot clark, phd, farvo, NORTH TEXAS EYE RESEARCH INSTITUTE

“Discovery of new glaucoma molecular pathogenic pathways and novel therapeutic approaches”

Featured Speakers:

  • Markus Kuehn, PhD, Glaucoma Cell Biology Laboratory, University of Iowa – Carver College of Medicine
  • Ross Collery, PhD, Department of Ophthalmology and Visual Sciences Eye Institute, Medical College of Wisconsin
  • Daniel Lipinski, MSc, PhD, Department of Ophthalmology and Visual Sciences Eye Institute, Medical College of Wisconsin


Dr. Clark’s laboratory studies the cell and molecular mechanisms responsible for a variety of eye diseases, especially glaucoma. Glaucoma is a leading cause of irreversible vision loss and blindness in the world. Dr. Clark’s lab has discovered a number of new disease pathways involved in glaucomatous elevation of intraocular pressure. His lab also has identified novel neuroprotective therapies to protect specific retinal neurons, retinal ganglion cells, that are damaged in glaucoma, and also protect the optic nerve and visual centers in the brain. Abe currently mentors 9 graduate students and serves on the editorial board of 4 scientific journals. He has published over 190 peer-reviewed manuscripts and has been invited to present his scientific work at over 110 national and international scientific meetings.


8:00 – 8:20 AM   Breakfast

8:20 – 8:30 AM   Chair’s Welcome: Terri Young, MD, MBA

Session I   Retinal and RPE Pathologies // Moderator: Curtis Brandt, PhD, FARVO

  • 8:30 – 8:50 AM Ross F. Collery, PhD, Medical College of Wisconsin Eye Institute // Assessing the Roles of Interphotoreceptor Retinoid-Binding Protein (IRBP) and IRBP-like Proteins in the Zebrafish Eye
  • 8:50 – 9:10 AM Gillian Shaw, DVM, DACVP, PhD // Ocular Manifestations of Hyperviscosity Syndrome in Dogs
  • 9:10 – 9:30 AM Amitha Domalpally, MD // Atrophy in Neovascular Age-Related Macular Degeneration
  • 9:30 – 9:50 AM Heather Schmitt, MS (PhD expected in Spring ‘18) // Overexpression of Histone Deacetylase-3 (HDAC3) Induces Apoptosis in Differentiated Retinal Neurons
  • 9:50 – 10.05 AM Krista Christensen, MPH, PhD // Macular Pigment and Vision Function Among Older Women in the 2nd Carotenoids in Age-Related Eye Disease Study (CAREDS2), Ancillary Study of the Women’s Health Initiative

10:05 – 10:25 AM   Break

Session II  Clinical and Translational Advancements // Moderator: Anna Momont, MD

  • 10:25 – 10:45 AM  Daniel Lipinski, MSc, DPhil, Medical College of Wisconsin Eye Institute // Development of an Inducible Anti-VEGF Gene Therapy for Age-Related Macular Degeneration
  • 10:45 – 11:05 AM  Pawan Shahi, PhD // Gene Therapy Alleviates KCNJ13 Defect Toward Curing Blindness
  • 11:05 – 11:25 AM   Nader Sheibani, PhD // Vitamin D Inhibits Angiogenesis By Promoting Vessel Maturation
  • 11:25 – 11:45 AM Ellie Corkery // Correlation of Optical Coherence Tomography Angiography Vascular Density to Color ETDRS Severity Level in Eyes with Diabetic Retinopathy
  • 11:45 – 12:00 PM Divya Sinha, PhD // Gene Augmentation in Best Vitelliform Macular Dystrophy

12:00 PM – 1:00 PM   Lunch by Good Food Company, Rooms 1220-21

Session III   Glaucoma and Optic Nerve // Moderator: T. Michael Nork, MD

  • 1:00 – 1:20 PM Markus Kuehn, PhD, University of Iowa, Center for the Prevention and Treatment of Visual Loss, Iowa City Veterans Affairs Medical Center // Cellular Strategies for Functional Regeneration of the Trabecular Meshwork
  • 1:20 – 1:40 PM Stuart Tompson, PhD // The TEK-ANGPT Pathway in Primary Congenital Glaucoma
  • 1:40 – 2:00 PM Robert Nickells, PhD // Kinetics of BAX Recruitment in RGCs After Optic Nerve Damage
  • 2:00 – 2:20 PM Gillian McLellan, BVMS, PhD, DECVP, DACVO // Distal Aqueous Outflow Pathways in a Spontaneous Model of Primary Congenital Glaucoma (PCG)
  • 2:20 – 2:35 PM   Paul Kaufman, MD // Why Can’t We Transfect/Transduce the TM in Live Monkeys with Transgenes that Affect Cellular Contractility and the Cytoskeleton, When We Can Do So in Monkey Organ-Cultured Anterior Segments, and We Can Do So with GFP in Live Monkeys Using Either FIV or scAAV Vectors?

2:35 – 2:45 PM Break

2:45 – 3:45 PM   Kambara Lecturer: Abbot Clark, PhD, FARVO // Discovery of New Glaucoma Molecular Pathogenic Pathways and Novel Therapeutic Approaches

3:45 – 4:00 PM   Closing Remarks: Terri Young, MD, MBA


Symposium Supported by the George Kambara Education Fund and McPherson Eye Research Institute.


March 16, 2018
8:00 am - 4:00 pm
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