DISEASE: Actinic keratosis

PATHOGENESIS: Develops on sun-exposed skin of fair-skinned, middle-aged individuals.

HISTOLOGY FEATURES: Irregular hyperkeratosis surface plaque parakeratosis and acanthosis. Actinic elastosis in substantia propria. Chronic inflammatory cell infiltrate in superficial dermis.

OCULAR FEATURES: Pre-cancerous squamous lesion, with risk of transformation and metastatic dissemination 0.5 - 3.0%.