Fundus Photograph Reading Center

Leader in Ophthalmic Image Evaluation since 1970

The Fundus Photograph Reading Center (FPRC) was founded on the enduring principles of intellectual honesty, quality, relevance, innovation and staff satisfaction. We are the core imaging lab within the University of Wisconsin – Madison Department of Ophthalmology and Visual Sciences studying diabetic retinopathy, age-related macular degeneration, uveitis and many more.

We serve a wide range of academic institutions, foundations, pharmaceutical companies and biotech firms including the National Eye Institute, National Institute of Diabetes and Digestive Kidney Diseases, Diabetic Retinopathy Clinical Research Network and the Department of Defense.

 

Meet the FPRC Team

Fundus Photograph Reading Center

Barbara A. Blodi

Professor, Medical Director of the Fundus Photograph Reading Center and Clinical Trials Unit

608-263-7290

Fundus Photograph Reading Center
Fundus Photograph Reading Center

Amitha Domalpally

Ophthalmologist; Research Director of the Fundus Photograph Reading Center

608-263-1088

Fundus Photograph Reading Center
Fundus Photograph Reading Center

Michael M. Altaweel

Professor; Co-Director of the Fundus Photograph Reading Center

608-263-7290

Fundus Photograph Reading Center
Fundus Photograph Reading Center

Matthew D. Davis

Professor Emeritus; Founder of the Fundus Photograph Reading Center

608-262-1334

Fundus Photograph Reading Center

Heather Baumhauer

Senior Admin Program Specialist

(608) 265-8794

Fundus Photograph Reading Center

Services

For early phase clinical trials, we offer a streamlined approach tailored to the needs of the study and sponsor.

  • Consultation on protocol design
  • Project management
  • Image analysis
  • Certification and regulatory compliance

 

 

Workflow:

  • Consultation on protocol design
  • Defining ocular disease outcomes
  • Study protocol/start-up training
  • On Site/off Site and web based training on imaging protocols
  • Certification of photography equipment and operators
  • Project management
  • Electronic upload of digital images
  • DICOM conversion
  • Inventory tracking
  • Query monitoring
  • Image quality monitoring and reporting
  • Reproducibility reports for evaluation data
  • Collaboration on manuscript preparation
  • Storage and archival of study images

Evaluation Types

  • Diabetic retinopathy
  • Age-related macular degeneration
  • Macular Edema
  • Vein Occlusion
  • Infectious and non-infectious Uveitis
  • Cytomegalovirus retinitis
  • Lens opacities
  • Glaucoma and neurodegenerative diseases
  • Safety studies to monitor toxicity

Image Evaluations

  • Optical Coherence Tomography (quantitative and layer analysis)
  • Fundus autofluorescence (SLO and camera-based)
  • Color fundus photography
  • Fluorescein and ICG angiograms
  • Red reflex, retroillumination and slit lamp lens photographs

Regulatory Compliance

  • Independent Quality Assurance workgroup, reporting directly to the General Manager
  • FPRC Documentation is compliant with ICH (International Conference on Harmonisation) guidelines and global regulatory requirements.
  • FPRC developed software is compliant with 21 CFR Part 11, ICH and other applicable global regulatory requirements.
  • FPRC staff are trained in HIPAA, human subjects and regulatory compliance and follow a detailed set of policies and standard operating procedures (SOPs).
  • Expert FDA hearing support

Imaging

All imaging technicians and equipment participating in any of our studies are required to be certified by the UW-FPRC for each specific study and each specific procedure within that study, prior to submitting study participant images.

ACTIVE GRANTS

COMING SOON

recent publications

Angiopoietin-1 is Required for Schlemm’s Canal Development in Mice and Humans

Jan 18 2018 // Thomson BR, Souma T, Tompson SW, Onay T, Kizhatil K, Siggs OM, Feng L, Whisenhunt KN, Yanovitch TL, Kalaydjieva L, Azmanov DN, Finzi S, Tanna CE, Hewitt AW, Mackey DA, Bradfield YS, Souzeau E, Javadiyan… Read More

Angiopoietin-1 is Required for Schlemm’s Canal Development in Mice and Humans

Phylogenetic and Recombination Analysis of The Herpesvirus Genus Varicellovirus

Jan 16 2018 // Kolb AW, Lewin AC, Moeller R, McLellan GJ, Brandt CR. Phylogenetic and recombination analysis of the herpesvirus genus varicellovirus. BMC Genomics. 2017 Nov 21;18(1):887. doi: 10.1186/s12864-017-4283-4. Read More

Phylogenetic and Recombination Analysis of The Herpesvirus Genus Varicellovirus

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

Jan 12 2018 // Aktas Z, Rao H, Slauson SR, Gabelt BT, Larsen IV, Sheridan RTC, Herrnberger L, Tamm ER, Kaufman PL, Brandt CR. Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork. Invest Ophthalmol Vis… Read More

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork

Long-term Efficacy and Safety of Latanoprostene Bunod 0.024% in Subjects With Open-Angle Glaucoma or Ocular Hypertension: Integrated Analysis of Two Phase 3 Studies

Jan 12 2018 // Weinreb RN, Liebmann JM, Martin KR, Kaufman PL, Vittitow JL: Long-term Efficacy and Safety of Latanoprostene Bunod 0.024% in Subjects with Open-Angle Glaucoma or Ocular Hypertension: Integrated Analysis of Two Phase 3 Studies. J Glaucoma… Read More

Long-term Efficacy and Safety of Latanoprostene Bunod 0.024% in Subjects With Open-Angle Glaucoma or Ocular Hypertension: Integrated Analysis of Two Phase 3 Studies

Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study

Oct 01 2017 // Lin H, Mares JA, LaMonte MJ, Brady WE, Sahli MW, Klein R, Klein BEK, Nie J, Millen AE. Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in… Read More

Association between Dietary Xanthophyll (Lutein and Zeaxanthin) Intake and Early Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study

Sep 26 2017 // Sobrin L, Chong YH, Fan Q, Gan A, Stanwyck LK, Kaidonis G, Craig JE, Kim J, Liao WL, Huang YC, Lee WJ, Hung YJ, Guo X, Hai Y, Ipp E, Pollack S, Hancock H, Price… Read More

Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study

 CONTACT US

310 N. Midvale Blvd, Suite 205
Madison, Wisconsin 53705
Phone: (608) 262-1334
Fax: (608) 265-9509

EMAIL US