A 42-year-old white man presented with a lower eyelid lesion and recurrent condylomata acuminata of his genitalia due to human papillomavirus (HPV) type 6a. Polymerase chain reaction analysis of both lesions was performed. The eyelid lesion was excised and found to be a papilloma caused by HPV6a infection. An extensive literature search revealed one previous report of concurrent conjunctival papilloma and genital papilloma involving HPV6a. Rare cases of solitary lesions of the eyelid secondary to HPV6a infection have been reported. HPV should be considered as a possible cause of an eyelid papilloma.