Adie Syndrome

PubMed ID: 30285366

Author(s): Sarao MS, Elnahry AG, Sharma S. Adie Syndrome. 2023 Jul 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from http://www.ncbi.nlm.nih.gov/books/NBK531471/ PMID 30285366

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Adie syndrome, also called the Holmes-Adie Syndrome, is named after William John Adie, the British neurologist of Australian descent, and Sir Gordon Morgan Holmes, an Irish neurologist. They both reported the condition in 1931, where Adie named it Pseudo-Argyll Robertson pupil. Earlier in 1881, Hughlings Jackson had described mydriasis with pupillary paralysis, while in 1906, Markus first described the tonic pupil. In 1914, Oloff had shown that tonic pupils could be caused by factors other than syphilis. Adie syndrome is a relatively common neurological disorder of unknown etiology comprising unilateral or bilateral tonically dilated pupils with light-near dissociation and tendon areflexia. The symptoms result from autonomic disturbances, affecting vasomotor and sudomotor functions. It has a female preponderance with absent or reduced deep tendon reflexes. The patient tends to have progressive miosis, bilateral affection (4% each year), and progressive loss of deep tendon reflexes. It can be associated with hypohidrosis, in this case, it is known as Ross syndrome.