Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis.

PubMed ID: 40689128

Author(s): Motevasseli T, Seraj A, Daftarian N, Kanav MR, Ahmadieh H, Sheibani N. Intracellular Signaling Pathways and Their Potential Targeting for Treatment of Ocular Posterior Segment Fibrosis. J Ophthalmic Vis Res. 2025 May 21;20:10.18502/jovr.v20.16966. doi: 10.18502/jovr.v20.16966. eCollection 2025. PMID 40689128

Journal: Journal Of Ophthalmic & Vision Research, Volume 20, 2025

Treatment of posterior segment fibrosis is an unmet challenge in ophthalmology. Fibrotic responses complicate the pathology and treatment of age-related macular degeneration, diabetic retinopathy, retinal detachment, and other retinal diseases resulting in severe visual impairment. There is a lack of clear understanding of the exact mechanisms and different cell types taking part in retinal and preretinal fibrosis. This review discusses the current knowledge regarding various aspects of the intracellular signaling pathways impacting vitreoretinal fibrotic processes, focusing on the cellular and molecular mechanisms, summarizing the results of preclinical and clinical studies, and suggesting strategies for future investigations.