Do’s and Don’ts” for intraarterial chemotherapy for retinoblastoma- What ophthalmologist and interventional radiologist need to know?

PubMed ID: 40434466

Author(s): Bhatter P, Parthasarathy R, Gupta V, Dusa SR, Aggarwal U, Das S, Kumar P. Do’s and Don’ts” for intraarterial chemotherapy for retinoblastoma- What ophthalmologist and interventional radiologist need to know? Indian J Ophthalmol. 2025 Jun 1;73(6):916-919. doi: 10.4103/IJO.IJO_2912_24. Epub 2025 May 28. PMID 40434466

Journal: Indian Journal Of Ophthalmology, Volume 73, Issue 6, Jun 2025

Intra-arterial chemotherapy (IAC) has emerged as the primary treatment option for retinoblastoma management. It enables the localized delivery of a higher concentration of chemotherapeutic agents (melphalan, carboplatin and topotecan) in the ophthalmic artery, enhancing tumour control and potentially avoiding the need for enucleation. Nevertheless, procedure-related complications have raised concerns. In this article, we outline the various technical considerations for performing safe IAC and minimizing procedure-related complications.