Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point-A Delphi Study: Classification of Atrophy Meetings Report 7.

PubMed ID: 40469898

Author(s): Wu Z, Sadda SR, Ach T, Blodi BA, Bottoni F, Chakravarthy U, Chew EY, Curcio CA, Ferris FL 3rd, Fleckenstein M, Freund KB, Grunwald JE, Holz FG, Jaffe GJ, Liakopoulos S, Lim TH, Mones JM, Pagliarini S, Pauleikhoff D, Pfau M, Rosenfeld PJ, Sarraf D, Schmitz-Valckenberg S, Spaide RF, Sparrow JR, Staurenghi G, Tufail A, Viola F, Guymer RH. Onset of End-Stage Atrophic Age-Related Macular Degeneration as an End Point-A Delphi Study: Classification of Atrophy Meetings Report 7. Ophthalmol Sci. 2025 Mar 28;5(5):100777. doi: 10.1016/j.xops.2025.100777. eCollection 2025 Sep-Oct. PMID 40469898

Journal: Ophthalmology Science, Volume 5, Issue 5, 2025

PURPOSE To investigate whether consensus can be reached on the acceptability of end-stage atrophy onset as a clinical end point in early intervention trials of age-related macular degeneration (AMD), and the criteria for defining such an end point.

DESIGN A modified Delphi study.

PARTICIPANTS International panel of experts in AMD, retinal imaging, and histopathology that are part of the Classification of Atrophy Meetings group.

METHODS A modified Delphi study was undertaken to determine if there is consensus on the acceptability of the onset of end-stage atrophic AMD as a clinical end point to evaluate early interventions and the criteria for defining such an end point. Two initial rounds of online surveys were conducted. Aggregate results and anonymized comments were provided after each round, followed by a face-to-face meeting before a final survey round was completed.

MAIN OUTCOME MEASURES Statements where consensus was reached, defined as ≥80% of responses within the 3-point bracket for agreement or disagreement based on a 9-point Likert rating scale, from a total of 33 statements included in the final round of the survey.

RESULTS Consensus was reached for the statement that the onset of end-stage atrophic AMD was an appropriate clinical end point to evaluate early interventions (82% responses in agreement). Consensus was also reached for the statement that such an end point should be defined based on anatomical changes that have been previously shown in clinical studies to be associated with marked, but not necessarily complete, functional loss (95% responses in agreement). Consensus was nearly reached for the specific criterion that ≥90% of such atrophic AMD lesions should have ≥1 test location that was ≤10 decibels on 2 microperimetry tests (77% responses in agreement).

CONCLUSIONS There was expert group consensus that the onset of end-stage atrophy is an appropriate clinical end point to evaluate early interventions in AMD, and that such an end point should show evidence of marked functional loss in prior clinical studies. We believe these findings will help to define incident clinical end points that are acceptable to regulatory authorities.

FINANCIAL DISCLOSURES Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.