Fundus Photograph Reading Center

Leader in Ophthalmic Image Evaluation since 1970

We are the core imaging lab within the University of Wisconsin – Madison Department of Ophthalmology and Visual Sciences studying diabetic retinopathy, age-related macular degeneration, uveitis and other ophthalmic diseases.The Fundus Photograph Reading Center (FPRC) was founded on the enduring principles of intellectual honesty, quality, relevance, innovation and staff satisfaction.

We serve a wide range of academic institutions, foundations, pharmaceutical companies and biotech firms including the National Eye Institute, National Institute of Diabetes and Digestive Kidney Diseases, Diabetic Retinopathy Clinical Research Network and the Department of Defense.

 

Services

For early phase clinical trials, we offer a streamlined approach tailored to the needs of the study and sponsor.

  • Consultation on protocol design
  • Project management
  • Image analysis
  • Certification and regulatory compliance

 

 

Workflow:

  • Consultation on protocol design
  • Defining ocular disease outcomes
  • Study protocol/start-up training
  • On Site/off Site and web based training on imaging protocols
  • Certification of photography equipment and operators
  • Project management
  • Electronic upload of digital images
  • DICOM conversion
  • Inventory tracking
  • Query monitoring
  • Image quality monitoring and reporting
  • Reproducibility reports for evaluation data
  • Collaboration on manuscript preparation
  • Storage and archival of study images

Evaluation Types

  • Diabetic retinopathy
  • Age-related macular degeneration
  • Macular Edema
  • Vein Occlusion
  • Infectious and non-infectious Uveitis
  • Cytomegalovirus retinitis
  • Lens opacities
  • Glaucoma and neurodegenerative diseases
  • Safety studies to monitor toxicity

Image Evaluations

  • Optical Coherence Tomography (quantitative and layer analysis)
  • Fundus autofluorescence (SLO and camera-based)
  • Color fundus photography
  • Fluorescein and ICG angiograms
  • Red reflex, retroillumination and slit lamp lens photographs

Regulatory Compliance

  • Independent Quality Assurance workgroup, reporting directly to the General Manager
  • FPRC Documentation is compliant with ICH (International Conference on Harmonisation) guidelines and global regulatory requirements.
  • FPRC developed software is compliant with 21 CFR Part 11, ICH and other applicable global regulatory requirements.
  • FPRC staff are trained in HIPAA, human subjects and regulatory compliance and follow a detailed set of policies and standard operating procedures (SOPs).
  • Expert FDA hearing support

Imaging

All imaging technicians and equipment participating in any of our studies are required to be certified by the UW-FPRC for each specific study and each specific procedure within that study, prior to submitting study participant images.

ACTIVE GRANTS

COMING SOON

recent publications and NEWS

Patient-Reported Visual Function Outcomes After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal or Hemiretinal Vein Occlusion: Preplanned Secondary Analysis of a Randomized Clinical Trial.

Jun 07 2019 // PubMed ID: 31169862 Author(s): Scott IU, VanVeldhuisen PC, Barton F, Oden NL, Ip MS, Blodi BA, Worrall M, Fish GE; Study of Comparative Treatments for Retinal Vein Occlusion 2 Investigator Group. Patient-Reported Visual Function Outcomes… Read More

Patient-Reported Visual Function Outcomes After Anti-Vascular Endothelial Growth Factor Therapy for Macular Edema Due to Central Retinal or Hemiretinal Vein Occlusion: Preplanned Secondary Analysis of a Randomized Clinical Trial.

Linking neural and clinical measures of glaucoma with diffusion magnetic resonance imaging (dMRI).

Jun 01 2019 // PubMed ID: 31150402 Author(s): Miller N, Liu Y, Krivochenitser R, Rokers B. Linking neural and clinical measures of glaucoma with diffusion magnetic resonance imaging (dMRI). PLoS One. 2019 May 31;14(5):e0217011. doi: 10.1371/journal.pone.0217011. eCollection 2019. Journal:… Read More

Linking neural and clinical measures of glaucoma with diffusion magnetic resonance imaging (dMRI).

Correction: Using HSV-1 Genome Phylogenetics to Track Past Human Migrations.

May 31 2019 // PubMed ID: 31145764 Author(s): Kolb AW, Ané C, Brandt CR. Correction: Using HSV-1 Genome Phylogenetics to Track Past Human Migrations. PLoS One. 2019 May 30;14(5):e0217890. doi: 10.1371/journal.pone.0217890. eCollection 2019. Journal: Plo S One, Volume 14,… Read More

Correction: Using HSV-1 Genome Phylogenetics to Track Past Human Migrations.

Early adoption of the fluocinolone acetonide (FAc) intravitreal implant in patients with persistent or recurrent diabetic macular edema (DME).

May 23 2019 // PubMed ID: 31114396 Author(s): McCluskey JD, Kaufman PL, Wynne K, Lewis G. Early adoption of the fluocinolone acetonide (FAc) intravitreal implant in patients with persistent or recurrent diabetic macular edema (DME). Int Med Case Rep… Read More

Early adoption of the fluocinolone acetonide (FAc) intravitreal implant in patients with persistent or recurrent diabetic macular edema (DME).

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

May 19 2019 // PubMed ID: 31101854 Author(s): Journal: Laboratory Investigation; A Journal Of Technical Methods And Pathology, May 2019 Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an… Read More

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

In-utero epigenetic factors are associated with early-onset myopia in young children.

May 18 2019 // PubMed ID: 31100065 Author(s): Seow WJ, Ngo CS, Pan H, Barathi VA, Tompson SW, Whisenhunt KN, Vithana E, Chong YS, Juo SH, Hysi P, Young TL, Karnani N, Saw SM. In-utero epigenetic factors are associated… Read More

In-utero epigenetic factors are associated with early-onset myopia in young children.

 CONTACT US

310 N. Midvale Blvd, Suite 205
Madison, Wisconsin 53705
Phone: (608) 262-1334
Fax: (608) 265-9509

EMAIL US