Fundus Photograph Reading Center

Leader in Ophthalmic Image Evaluation since 1970

We are the core imaging lab within the University of Wisconsin – Madison Department of Ophthalmology and Visual Sciences studying diabetic retinopathy, age-related macular degeneration, uveitis and other ophthalmic diseases.The Fundus Photograph Reading Center (FPRC) was founded on the enduring principles of intellectual honesty, quality, relevance, innovation and staff satisfaction.

We serve a wide range of academic institutions, foundations, pharmaceutical companies and biotech firms including the National Eye Institute, National Institute of Diabetes and Digestive Kidney Diseases, Diabetic Retinopathy Clinical Research Network and the Department of Defense.

 

Services

For early phase clinical trials, we offer a streamlined approach tailored to the needs of the study and sponsor.

  • Consultation on protocol design
  • Project management
  • Image analysis
  • Certification and regulatory compliance

 

 

Workflow:

  • Consultation on protocol design
  • Defining ocular disease outcomes
  • Study protocol/start-up training
  • On Site/off Site and web based training on imaging protocols
  • Certification of photography equipment and operators
  • Project management
  • Electronic upload of digital images
  • DICOM conversion
  • Inventory tracking
  • Query monitoring
  • Image quality monitoring and reporting
  • Reproducibility reports for evaluation data
  • Collaboration on manuscript preparation
  • Storage and archival of study images

Evaluation Types

  • Diabetic retinopathy
  • Age-related macular degeneration
  • Macular Edema
  • Vein Occlusion
  • Infectious and non-infectious Uveitis
  • Cytomegalovirus retinitis
  • Lens opacities
  • Glaucoma and neurodegenerative diseases
  • Safety studies to monitor toxicity

Image Evaluations

  • Optical Coherence Tomography (quantitative and layer analysis)
  • Fundus autofluorescence (SLO and camera-based)
  • Color fundus photography
  • Fluorescein and ICG angiograms
  • Red reflex, retroillumination and slit lamp lens photographs

Regulatory Compliance

  • Independent Quality Assurance workgroup, reporting directly to the General Manager
  • FPRC Documentation is compliant with ICH (International Conference on Harmonisation) guidelines and global regulatory requirements.
  • FPRC developed software is compliant with 21 CFR Part 11, ICH and other applicable global regulatory requirements.
  • FPRC staff are trained in HIPAA, human subjects and regulatory compliance and follow a detailed set of policies and standard operating procedures (SOPs).
  • Expert FDA hearing support

Imaging

All imaging technicians and equipment participating in any of our studies are required to be certified by the UW-FPRC for each specific study and each specific procedure within that study, prior to submitting study participant images.

ACTIVE GRANTS

COMING SOON

recent publications and NEWS

Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells.

Aug 09 2019 // PubMed ID: 31391478 Author(s): Alharbi Y, Kapur A, Felder M, Barroilhet L, Stein T, Pattnaik BR, Patankar MS. Plumbagin-induced oxidative stress leads to inhibition of Na(+)/K(+)-ATPase (NKA) in canine cancer cells. Sci Rep. 2019 Aug… Read More

Plumbagin-induced oxidative stress leads to inhibition of Na+/K+-ATPase (NKA) in canine cancer cells.

Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults.

Aug 07 2019 // PubMed ID: 31385821 Author(s): Paulsen AJ, Schubert CR, Pinto A, Carlsson CM, Chappell RJ, Fischer ME, Klein BEK, Klein R, Tsai MY, Cruickshanks KJ. Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study… Read More

Neuroprotective Biomarkers and Cognitive Function in a Long-Term Prospective Population-based Study of Aging US Adults.

Scaling Up Teleophthalmology for Diabetic Eye Screening: Opportunities for Widespread Implementation in the USA.

Aug 04 2019 // PubMed ID: 31375932 Author(s): Liu Y, Torres Diaz A, Benkert R. Scaling Up Teleophthalmology for Diabetic Eye Screening: Opportunities for Widespread Implementation in the USA. Curr Diab Rep. 2019 Aug 2;19(9):74. doi: 10.1007/s11892-019-1187-5. Review. Journal:… Read More

Scaling Up Teleophthalmology for Diabetic Eye Screening: Opportunities for Widespread Implementation in the USA.

The association of retinal vessel calibres with heart failure and long-term alterations in cardiac structure and function: the Atherosclerosis Risk in Communities (ARIC) Study.

Aug 03 2019 // PubMed ID: 31373139 Author(s): Chandra A, Seidelmann SB, Claggett BL, Klein BE, Klein R, Shah AM, Solomon SD. The association of retinal vessel calibres with heart failure and long-term alterations in cardiac structure and function:… Read More

The association of retinal vessel calibres with heart failure and long-term alterations in cardiac structure and function: the Atherosclerosis Risk in Communities (ARIC) Study.

Relationship Between Diet, Tinnitus, and Hearing Difficulties.

Jul 30 2019 // PubMed ID: 31356390 Author(s): Dawes P, Cruickshanks KJ, Marsden A, Moore DR, Munro KJ. Relationship Between Diet, Tinnitus, and Hearing Difficulties. Ear Hear. 2019 Jul 25. doi: 10.1097/AUD.0000000000000765. [Epub ahead of print] Journal: Ear And… Read More

Relationship Between Diet, Tinnitus, and Hearing Difficulties.

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.

Jul 20 2019 // PubMed ID: 31323684 Author(s): Iglesias AI, Ong JS, Khawaja AP, Gharahkhani P, Tedja MS, Verhoeven VJM, Bonnemaijer PWM, Wolfs RCW, Young TL, Jansonius NM, Craig JE, Stambolian D, van Duijn CM, MacGregor S, Klaver CCW;… Read More

Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.

 CONTACT US

310 N. Midvale Blvd, Suite 205
Madison, Wisconsin 53705
Phone: (608) 262-1334
Fax: (608) 265-9509

EMAIL US