Retrolental fibroplasia: I. Clinical observations.

PubMed ID: 576399

Author(s): Flynn JT, O’Grady GE, Herrera J, Kushner BJ, Cantolino S, Milam W. Retrolental fibroplasia: I. Clinical observations. Arch Ophthalmol. 1977 Feb;95(2):217-23.

Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 95, Issue 2, Feb 1977

The changes occurring in retrolental fibroplasia were studied in 97 premature infants with fundus photography and fluorescein angiography. The macrovascular lesion of proliferative retrolental fibroplasia was identified as a functioning arteriovenous shunt. The microvascular abnormalities were capillary tufts, collaterals, capillary-free zones, and neovascular membranes. Regression was signaled by the ingrowth of capillaries from the shunt into the avascular retina. Cicatrization was characterized by persistence of the vascular abnormalities of the proliferative phase and organization of the avascular retina into a contracting scar.