Eye malformations in rats: induction by prenatal exposure to nickel carbonyl.

Daniel Albert // Publications // Feb 09 1979

PubMed ID: 104388

Author(s): Sunderman FW Jr, Allpass PR, Mitchell JM, Baselt RC, Albert DM. Eye malformations in rats: induction by prenatal exposure to nickel carbonyl. Science. 1979 Feb 9;203(4380):550-3. PMID 104388

Journal: Science (New York, N.Y.), Volume 203, Issue 4380, Feb 1979

Exposure of pregnant rats to inhalation of nickel carbonyl on days 7 or 8 of gestation frequently causes the progeny to develop ocular anomalies, including anophthalmia and microphthalmia. The incidence of extraocular anomalies is very low. The specificity of nickel carbonyl for induction of ocular anomalies in rats appears to be unique among known teratogenic agents.