An investigation into the association between liver damage and metastatic uveal melanoma.

Daniel Albert // Publications // Sep 15 1985

PubMed ID: 4037035

Author(s): Pascal SG, Saulenas AM, Fournier GA, Seddon JM, Hatfield RM, Albert DM. An investigation into the association between liver damage and metastatic uveal melanoma. Am J Ophthalmol. 1985 Sep 15;100(3):448-53. PMID 4037035

Journal: American Journal Of Ophthalmology, Volume 100, Issue 3, Sep 1985

We examined the effect of liver damage induced by carbon tetrachloride on the incidence of hepatic metastasis in the Greene hamster melanoma. Nine of 17 animals with liver damage had melanoma growth in the liver after the intraportal vein injection of tumor cells, whereas tumor growth occurred in four of 27 control animals (P less than .01). These results suggest that, in this model, liver damage predisposes to metastatic involvement by melanoma.