Author(s): Gamel JW, Greenberg RA, McLean IW, Seddon JM, Albert DM, Naids RE, Folberg R, Donoso LA. A clinically useful method for combining gross and microscopic measurements to select high-risk patients after enucleation for ciliochoroidal melanoma. Cancer. 1986 Apr 1;57(7):1341-4. PMID 2418937
Journal: Cancer, Volume 57, Issue 7, Apr 1986
An objective and reproducible method was devised for estimating the malignant potential of ciliochoroidal melanomas after enucleation. This method requires only a single, routine microslide from which nucleolar area and largest tumor dimension are measured. Previous studies have shown these measurements to be reproducible and highly correlated with mortality. To demonstrate a practical method for clinical application of these measurements, a Cox statistical model was derived from 200 cases supplied by the Armed Forces Institute of Pathology. The resulting model, when applied to 340 cases with known outcome from two independent laboratories, allowed subdivision of patients into groups that suffered a six-fold difference in mortality. These results suggest that a central registry, by applying this method to histologic slides from around the world, could provide information useful for the clinical management of patients enucleated for ciliochoroidal melanoma.