Author(s): Diesenhouse MC, Palay DA, Newman NJ, To K, Albert DM. Acquired heterochromia with horner syndrome in two adults. Ophthalmology. 1992 Dec;99(12):1815-7. PMID 1480396
Journal: Ophthalmology, Volume 99, Issue 12, Dec 1992
BACKGROUND Heterochromia iridis, asymmetry of iris pigmentation, has been well described with congenital Horner syndrome. Acquired heterochromia associated with lesions in the ocular sympathetic pathways in adulthood, however, is rare.
METHODS Two cases are reported in which sympathectomy in adults resulted in ipsilateral Horner syndrome with heterochromia. In each case, pharmacologic testing with cocaine and hydroxyamphetamine was performed.
RESULTS In both cases, sympathectomy occurred at the level of the second order neuron, but hydroxyamphetamine testing suggested at least partial third order neuron involvement.
CONCLUSION Acquired heterochromia can occur in adults. The partial response to hydroxyamphetamine in the two cases presented may reflect trans-synaptic degeneration of the postganglionic neuron. A reduction in trophic influences on iris melanocytes may have contributed to the observed heterochromia.