Mitomycin C suppresses aqueous human flow in cynomolgus monkeys.

PubMed ID: 7864759

Author(s): Kee C, Pelzek CD, Kaufman PL. Mitomycin C suppresses aqueous human flow in cynomolgus monkeys. Arch Ophthalmol. 1995 Feb;113(2):239-42. PMID 7864759

Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 113, Issue 2, Feb 1995

OBJECTIVE To determine whether mitomycin C suppresses aqueous humor formation in cynomolgus monkeys.

METHODS Three monkeys received subconjunctival injections (50 microL) in four quadrants bilaterally, one eye receiving mitomycin C (0.5 mg/mL) and the other receiving distilled water. Seven monkeys underwent 360 degrees conjunctival peritomy bilaterally and episcleral application of mitomycin C-soaked (0.5 mg/mL) cellulose sponges for 5 minutes in all four quadrants unilaterally. Aqueous humor flow was measured fluorophotometrically 1 and 3 days, and 1, 2, and 4 weeks after subconjunctival injection; and 3 days and 1, 2, 3, and 4 weeks after episcleral application.

RESULTS There was no change in aqueous flow in either eye and no difference between eyes following subconjunctival injection. Aqueous flow was reduced by 8% +/- 7% (mean +/- SEM), 20% +/- 3% (P < .01), 9% +/- 10%, and 0% +/- 4% compared with contralateral controls 1, 2, 3, and 4 weeks, respectively, after episcleral application of mitomycin C.

CONCLUSIONS Episcleral application of mitomycin C can produce at least a modest short-term reduction of aqueous humor flow in primates. Reduced aqueous flow might contribute to early postoperative hypotony following trabeculectomy with mitomycin C.