Eyelid lymphatics I: histochemical comparisons between the monkey and human.

Kaufman Lab // Mark Lucarelli // Publications // Jan 01 2002

PubMed ID: 11910321

Author(s): Cook BE Jr, Lucarelli MJ, Lemke BN, Dortzbach RK, Kaufman PL, Forrest L, Greene E, Gabelt BT. Eyelid lymphatics I: histochemical comparisons between the monkey and human. Ophthalmic Plast Reconstr Surg. 2002 Jan;18(1):18-23. PMID 11910321

Journal: Ophthalmic Plastic And Reconstructive Surgery, Volume 18, Issue 1, Jan 2002

PURPOSE To study the lymphatic drainage of the cynomolgus monkey and human eyelid and periocular tissue by means of histochemistry.

METHODS Eyelid and periocular tissue from three cynomolgus monkeys undergoing sacrifice for glaucoma and retina research purposes and discarded tissue from a wedge resection of one human eyelid were used for histochemical analysis. Lymphatic capillaries were distinguished histochemically in monkey and human eyelids by light microscopy with a 5′-nucleotidase (5′-Nase) staining method. Identification of lymphatic vessels was based on strict morphologic criteria combined with specific 5′-Nase staining.

RESULTS Histochemical analysis with 5′-nucleotidase revealed a subcutaneous and pretarsal lymphatic plexus in both the human and monkey.

CONCLUSIONS Histochemical results demonstrate similar lymphatic plexi in the monkey and human. Future studies will help to clarify the lymphatic drainage pathways of monkey and human eyelids.