Potassium-dependent sodium-calcium exchange through the eye of the fly.

Nansi Colley // Publications // Nov 01 2002

PubMed ID: 12502573

Author(s): Webel R, Haug-Collet K, Pearson B, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ. Potassium-dependent sodium-calcium exchange through the eye of the fly. Ann N Y Acad Sci. 2002 Nov;976:300-14. Review. PMID 12502573

Journal: Annals Of The New York Academy Of Sciences, Volume 976, Nov 2002

In this review, we describe the characterization of a Drosophila sodium/calcium-potassium exchanger, Nckx30C. Sodium/calcium (-potassium) exchangers (NCX and NCKX) are required for the rapid removal of calcium in excitable cells. The deduced protein topology for NCKX30C is similar to that of mammalian NCKX, with 5 hydrophobic domains in the amino terminus separated from 6 at the carboxy-terminal end by a large intracellular loop. NCKX30C functions as a potassium-dependent sodium-calcium exchanger and is expressed in adult neurons and during ventral nerve cord development in the embryo. Nckx30C is expressed in a dorsal/ventral pattern in the eye-antennal disc, suggesting that large fluxes of calcium may be occurring during imaginal disc development in the larvae. NCKX30C may play a critical role in modulating calcium during development as well as in the removal of calcium and maintenance of calcium homeostasis in adults.