Author(s): Prasad SS, Schnerch A, Lam DY, To E, Jim J, Kaufman PL, Matsubara JA. Immunohistochemical investigations of neurofilament M’ and alphabeta-crystallin in the magnocellular layers of the primate lateral geniculate nucleus. Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):216-20. PMID 12531531
The magnocellular and parvocellular pathways are two major processing streams in the primate visual system. Using high-density grid arrayed cDNA clones to hybridize to cDNA probes from cortical regions of each pathway, a list of candidate differentially expressed genes was produced [Mol. Brain Res. 82 (2000) 11-24]. Magnocellular pathway candidates include neurofilament M’ and alphabeta-crystallin. Using antibodies generated against these proteins, immunohistochemical analysis revealed preferential staining of the magnocellular layers in the primate lateral geniculate nucleus, providing verification of two candidate magnocellular-enriched genes.