Postmenopausal hormone therapy and its association with cognitive impairment.

Cruickshanks Lab // Kleins Lab // Publications // Nov 10 2003

PubMed ID: 14609785

Author(s): Mitchell JL, Cruickshanks KJ, Klein BE, Palta M, Nondahl DM. Postmenopausal hormone therapy and its association with cognitive impairment. Arch Intern Med. 2003 Nov 10;163(20):2485-90. PMID 14609785

Journal: Archives Of Internal Medicine, Volume 163, Issue 20, Nov 2003

BACKGROUND Cognitive impairment is a common and potentially debilitating medical problem in older women. Postmenopausal hormone therapy (HT) has been associated with better cognitive function, but the literature is conflicting. Results of recent trials suggest that HT is inappropriate for prevention of heart disease, and we sought to determine the role of HT in the risk of cognitive impairment.

METHODS We measured HT use and cognitive function in a population-based cohort of 1462 postmenopausal women participating in the 5-year follow-up examination for the Epidemiology of Hearing Loss Study in 1998-2000. The cohort was defined in 1987-1988 by residency in Beaver Dam, Wis, and an age of 43 to 84 years. Women had also participated in the Beaver Dam Eye Study baseline examination in 1988-1990. Use of HT was assessed at the Beaver Dam Eye Study baseline (1988-1990), 5-year follow-up (1993-1995), and 10-year follow-up (1998-2000) visits. Cognitive impairment was defined as a low Mini-Mental State Examination score or a reported diagnosis of Alzheimer disease.

RESULTS Six percent of participants (n = 94) were impaired; these women were significantly older and less educated than those who were unimpaired. In age- and education-adjusted analysis, current HT use was not significantly associated with cognitive impairment (odds ratio, 0.6; 95% confidence interval, 0.2-1.3). Similarly, cognitive impairment was not associated with past HT use or duration of HT use.

CONCLUSION In this large population-based study, postmenopausal hormone therapy was not significantly associated with better cognitive function.