Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera.

Kleins Lab // Publications // Nov 01 2004

PubMed ID: 15534124

Author(s): Klein R, Meuer SM, Moss SE, Klein BE, Neider MW, Reinke J. Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera. Arch Ophthalmol. 2004 Nov;122(11):1642-6. PMID 15534124

Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 122, Issue 11, Nov 2004

OBJECTIVE To compare gradings of lesions associated with age-related macular degeneration (AMD) from digital and stereoscopic film images.

DESIGN Instrument validation study.

PARTICIPANTS Sixty-two subjects (124 eyes) with varying degrees of AMD, including no AMD.

METHODS Images of the optic disc and macula were taken using a 45 degrees digital camera (6.3 megapixels) through dark-adapted pupils and pharmacologically dilated pupils. In addition, 30 degrees stereoscopic retinal film images were taken through pharmacologically dilated pupils of the same eyes. All images were graded for drusen size, type, and area; pigmentary abnormalities; geographic atrophy; and neovascular lesions using the modified Wisconsin Age-Related Maculopathy Grading System. Exact agreement and unweighted kappa scores were calculated for paired gradings resulting from digital and film images.

MAIN OUTCOME MEASURE Agreement between gradings obtained from stereoscopic slide transparencies and digital nonstereoscopic images.

RESULTS Exact agreement between gradings of digital and stereoscopic film images taken through pharmacologically dilated pupils was 91% (kappa = 0.85) for the categories of none, early AMD, and late AMD. Exact agreement for gradings of digital images taken through dark-adapted pupils compared with gradings of film images was 80% (kappa = 0.69). Exact agreement for gradings of digital images captured through dark-adapted and pharmacologically dilated pupils was 86% (kappa = 0.78). In addition, kappa scores for agreement between different approaches for individual lesions were moderate to almost perfect.

CONCLUSIONS Gradings resulting from high-resolution digital images, especially when the pupil is pharmacologically dilated, are comparable with those resulting from film-based images. We conclude that digital imaging of the retina is useful for epidemiological studies of AMD.