Serum cotinine level and incident hearing loss: a case-control study.

Cruickshanks Lab // Kleins Lab // Publications // Nov 01 2004

PubMed ID: 15545578

Author(s): Nondahl DM, Cruickshanks KJ, Dalton DS, Schubert CR, Klein BE, Klein R, Tweed TS. Serum cotinine level and incident hearing loss: a case-control study. Arch Otolaryngol Head Neck Surg. 2004 Nov;130(11):1260-4. PMID 15545578

Journal: Archives Of Otolaryngology Head & Neck Surgery, Volume 130, Issue 11, Nov 2004

BACKGROUND A growing body of literature suggests an association between cigarette smoking and hearing loss.

OBJECTIVE To assess the relation between levels of serum cotinine, a biomarker of exposure to tobacco smoke, and incident hearing loss.

DESIGN A cross-sectional, incident, case-control study of participants selected from a population-based cohort.

SETTING Testing was conducted at the Beaver Dam Community Hospital, Beaver Dam, Wis.

PARTICIPANTS A total of 197 participants with incident hearing loss and 394 control participants, aged 53 to 75 years, selected from the 2800 participants of the 5-year follow-up examination of the population-based Epidemiology of Hearing Loss Study, 1998-2000.

MAIN OUTCOME MEASURE Incident hearing loss. The incidence of hearing loss was defined as a pure-tone average of thresholds at 500, 1000, 2000, and 4000 Hz greater than 25-dB hearing level in either ear at follow-up among those without hearing loss at baseline.

RESULTS No significant associations were found between serum cotinine levels and incident hearing loss.

CONCLUSIONS These results were not consistent with a previous report, which found cross-sectional associations between prevalent hearing loss and current smoking and environmental tobacco smoke exposure in the home. Longer-term longitudinal studies of smoking and/or serum cotinine levels and the subsequent development of hearing loss may help clarify these associations.