Putative aqueous humor misdirection syndrome as a cause of glaucoma in cats: 32 cases (1997-2003).

Publications // Richard Dubielzig // Nov 01 2005

PubMed ID: 16279388

Author(s): Czederpiltz JM, La Croix NC, van der Woerdt A, Bentley E, Dubielzig RR, Murphy CJ, Miller PE. Putative aqueous humor misdirection syndrome as a cause of glaucoma in cats: 32 cases (1997-2003). J Am Vet Med Assoc. 2005 Nov 1;227(9):1434-41. PMID 16279388

Journal: Journal Of The American Veterinary Medical Association, Volume 227, Issue 9, Nov 2005

OBJECTIVE To characterize the clinical and morphologic aspects of aqueous humor misdirection syndrome (AHMS) in cats and provide a hypothesis regarding its pathogenesis on the basis of detailed analysis of affected cats.

DESIGN Retrospective study.

ANIMALS 32 cats (40 eyes).

PROCEDURE Medical records of cats in which AHMS was diagnosed from July 1997 to August 2003 were reviewed. In certain cats, results of additional diagnostic testing were also obtained, including A-scan, B-scan, and high-resolution ultrasonography; streak retinoscopy; video keratometry; and infrared neutralizing videoretinoscopy as well as results of analysis of flash-frozen sections and histologic examination of enucleated globes.

RESULTS Cats had a uniformly shallow anterior chamber, intact lens zonules, and a narrowed approach to an open iridocorneal angle. Mean age of affected cats was 11.7 years (range, 4 to 16 years), and female cats were significantly more often affected than male cats. Clinical signs included mydriasis, decreased pupillary light reflex, decreased menace response, and blindness. Glaucomatous changes to the optic nerve, incipient cataracts, and eventual blindness were seen. Intraocular pressure was > or = 20 mm Hg (range, 12 to 58 mm Hg) in 32 of 40 eyes. Ultrasonography and histologic examination revealed a thickened anterior vitreal face interposed between the lens and ciliary body, partial ciliary cleft collapse, and cavitated vitreal regions. Various treatment modalities were used.

CONCLUSIONS AND CLINICAL RELEVANCE AHMS affects older cats, especially females, and may result in glaucoma, vision loss, and signs of ocular pain. Topical administration of carbonic anhydrase inhibitors decreased intraocular pressure.