Vitamin E in the treatment of uveitis-associated macular edema.

Matthew Davis // Publications // Jan 01 2006

PubMed ID: 16386999

Author(s): Nussenblatt RB, Kim J, Thompson DJ, Davis MD, Chew E, Ferris FL, Buggage R. Vitamin E in the treatment of uveitis-associated macular edema. Am J Ophthalmol. 2006 Jan;141(1):193-4. PMID 16386999

Journal: American Journal Of Ophthalmology, Volume 141, Issue 1, Jan 2006

PURPOSE To investigate whether high-dose alpha-tocopherol (vitamin E) could reduce vision loss and retinal thickening associated with uveitis-associated cystoid macular edema.

DESIGN A double-masked, randomized study.

METHODS Uveitis patients with macular edema seen at the NIH were randomized and received either 1600 IU/day of vitamin E or placebo for 4 months. Visual acuity and retinal thickening were collected for the efficacy and the safety of the high dose of vitamin E.

RESULTS Changes in visual acuity and retinal thickening.

CONCLUSIONS Four-month oral supplementation with 1600 IU/d of vitamin E had no apparent effect on uveitis-associated macular edema or visual acuity in this small study.