Author(s): Vrabec JP, Levin LA. Type II protein C deficiency in a 16-year-old girl with central retinal vein occlusion. Am J Ophthalmol. 2007 Feb;143(2):341-2. Epub 2006 Oct 2. PMID 17258526
Journal: American Journal Of Ophthalmology, Volume 143, Issue 2, Feb 2007
PURPOSE To report a case of central retinal vein occlusion in the setting of type II protein C deficiency, and to describe the appropriate tests for detecting this clotting abnormality.
DESIGN Observational case report.
METHODS Retrospective review of clinical examination and laboratory findings.
RESULTS A 16-year-old girl was evaluated for progressive monocular vision loss occurring over a period of one month. Dilated fundus examination and fluorescein angiography revealed the presence of a central retinal vein occlusion. Hypercoagulable work-up demonstrated normal protein C antigen levels, but a marked reduction in protein C function, confirming a type II protein C deficiency.
CONCLUSIONS Central retinal vein occlusion may be associated with type II protein C deficiency. Testing for protein C antigen levels and function is necessary for detection of both type I and type II protein C deficiency.