The neurobiology of cell death in glaucoma.

Leonard Levin // Publications // Dec 01 2007

PubMed ID: 18157171

Author(s): Vrabec JP, Levin LA. The neurobiology of cell death in glaucoma. Eye (Lond). 2007 Dec;21 Suppl 1:S11-4. Review. PMID 18157171

Journal: Eye (London, England), Volume 21 Suppl 1, Dec 2007

Glaucoma is an optic neuropathy in which the optic nerve axons are damaged, resulting in death of retinal ganglion cells (RGCs). The primary region of damage is thought to be the optic nerve head (ONH), with the lateral geniculate nucleus (LGN) and optic radiations to the visual cortex being secondarily affected. Neurotrophin deprivation resulting from optic nerve injury is thought to cause RGCs to die by apoptosis by inhibition of cell survival pathways. However, disruption of retrograde axonal transport is not the only mechanism associated with optic nerve damage and RGC death, and thus, an additional mechanism of injury is likely to be involved in glaucomatous optic neuropathy.