Changing patterns and outcome of Dengue infection; report from a tertiary care hospital in Pakistan.

Publications // Roomasa Channa // Sep 01 2008

PubMed ID: 18846796

Author(s): Wasay M, Channa R, Jumani M, Zafar A. Changing patterns and outcome of Dengue infection; report from a tertiary care hospital in Pakistan. J Pak Med Assoc. 2008 Sep;58(9):488-9. PMID 18846796

Journal: Jpma. The Journal Of The Pakistan Medical Association, Volume 58, Issue 9, Sep 2008

OBJECTIVE To identify predictors of outcome in patients with Dengue Infections at a tertiary care hospital and to analyze that if pattern of Dengue infection is changing in the past two years.

METHODS We reviewed 225 cases of confirmed dengue virus infection. The diagnosis was confirmed by presence of IgM antibodies against Dengue by ELISA in addition to fever according to WHO criteria.

RESULTS From years 2000-2004, 30 (73%) had Dengue Fever (DF), 10 (24%) had Dengue Haemorrhagic Fever (DHF) and 1(2.4%) had Dengue shock syndrome (DSS) while after 2005, 107 (58%) had DF, 71 (39%) had DHF and 6 (3%) had DSS. Six patients (2.6%) died. Presence of shock (OR 2.9, 95% CI; 1.7-6.2), coma at presentation (OR 1.89, 95% CI; 1.02-3.3) and seizures (OR 1.6, 95% CI; 0.9-3.0) were important predictors of mortality.

CONCLUSION These findings are suggestive of a change in pattern and outcome of Dengue at our institution. Larger data set from all around the country is needed to comment on epidemicity and endemicity pattern of the Dengue in Pakistan.