Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.

Publications // Yao Liu // Dec 01 2008

PubMed ID: 19145124

Author(s): Liu Y, Dinkin MJ, Loewenstein JI, Rizzo JF 3rd, Cestari DM. Multifocal electroretinographic abnormalities in ethambutol-induced visual loss. J Neuroophthalmol. 2008 Dec;28(4):278-82. doi: 10.1097/WNO.0b013e31818e3ece. PMID 19145124

Journal: Journal Of Neuro Ophthalmology : The Official Journal Of The North American Neuro Ophthalmology Society, Volume 28, Issue 4, Dec 2008

Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage. Multifocal electroretinography (mfERG) disclosed markedly low-amplitude responses at fixation and in the regions corresponding to the visual field defects. These results suggested that the visual dysfunction might be entirely attributable to retinal rather than optic nerve toxicity. These are the first reported patients to show mfERG abnormalities that correspond to bitemporal visual field defects and add to the growing evidence that ethambutol damages the retina.