PubMed ID: 21102448
Author(s): Hua Y, Sinha R, Martineau M, Kahms M, Klingauf J. A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nat Neurosci. 2010 Dec;13(12):1451-3. doi: 10.1038/nn.2695. PMID 21102448
Journal: Nature Neuroscience, Volume 13, Issue 12, Dec 2010
There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.