Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics.

Kleins Lab // Publications // May 01 2012

PubMed ID: 22330960

Author(s): Kuo JZ, Guo X, Klein R, Klein BE, Cui J, Rotter JI, Ipp E, Chen YD. Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics. Ophthalmology. 2012 May;119(5):1041-6. doi: 10.1016/j.ophtha.2011.10.040. Epub 2012 Feb 11. PMID 22330960

Journal: Ophthalmology, Volume 119, Issue 5, May 2012

PURPOSE To investigate the associations of serum amyloid A (SAA) protein and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) with diabetic retinopathy (DR) in Hispanics.

DESIGN Prospective, nonrandomized, cross-sectional, family-based observational cohort study.

PARTICIPANTS A total of 473 Hispanic type II diabetic subjects in families ascertained via proband with DR.

METHODS Levels of SAA, sTNF-R1, and sTNF-R2 were measured with enzyme-linked immunosorbent assay. Diabetic retinopathy was assessed by fundus photography and graded using modified Airlie House classification.

MAIN OUTCOME MEASURES Levels of SAA, sTNF-R1, and sTNF-R2 to severity of DR with and without covariates.

RESULTS A direct association of sTNF-R1 (2.37±0.13, 2.15±0.09, 3.09±0.24, 3.25±0.46, 5.02±0.61 ng/ml; P < 0.0001) and sTNF-R2 (6.04±0.20, 6.25±0.52, 7.96±0.70, 8.14±1.13, 14.83±1.68 ng/ml; P < 0.0001) was found for no DR, mild nonproliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR, respectively. These associations remained significant after adjusting for age, gender, body mass index, glycosylated hemoglobin, diabetes duration, systolic blood pressure, and serum creatinine (P < 0.0001 for sTNF-R1 and P=0.0004 for sTNF-R2). A similar pattern was observed when we adjusted for urinary albumin:creatinine ratio in place of serum creatinine (P=0.005 for sTNF-R1 and P=0.02 for sTNF-R2).

CONCLUSIONS Levels of sTNF-R1 and sTNF-R2 are highly correlated with the severity of DR, suggesting that inflammation and insulin resistance may play a critical role in the development of DR. These may be useful biomarkers for DR, aiding in etiologic studies and possibly identifying at-risk patients for active intervention.

Copyright © 2012 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.