Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration.

Publications // Roomasa Channa // Jan 01 2013

PubMed ID: 26097682

Author(s): Sadiq MA, Rashid A, Channa R, Hatef E, Do DV, Nguyen QD, Sepah YJ. Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration. Version 2. F1000Res. 2013 May 23 [revised 2015 Jan 1];2:131. doi: 10.12688/f1000research.2-131.v2. eCollection 2013. PMID 26097682

Journal: F1000 Research, Volume 2, 2013

PURPOSE To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus (TM) OCT, and the Spectral Domain (SD-OCT) Spectralis (TM) and Cirrus (TM) OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration.

DESIGN Prospective observational study.

METHODS

SETTING University-based retina practice.

PATIENTS Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD.

PROCEDURE OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices.

MAIN OUTCOME MEASURES Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability.

RESULTS Spectralis had the highest number of images needing manual correction.  All machines had high ICCs, with Spectralis having the highest.  Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™.  The CORs were lowest for Spectralis (TM) and similar and higher for Cirrus (TM) and Stratus (TM).  Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. 

CONCLUSION Agreement is low between devices, except between both SD-OCT machines.  Manual correction tends to improve results.