Circularity index as a risk factor for progression of geographic atrophy.

Amitha Domalpally // Publications // Ronald Danis // Dec 01 2013

PubMed ID: 24206616

Author(s): Domalpally A, Danis RP, White J, Narkar A, Clemons T, Ferris F, Chew E. Circularity index as a risk factor for progression of geographic atrophy. Ophthalmology. 2013 Dec;120(12):2666-2671. doi: 10.1016/j.ophtha.2013.07.047. Epub 2013 Oct 24. PMID 24206616

Journal: Ophthalmology, Volume 120, Issue 12, Dec 2013

OBJECTIVE To develop a parameter that can assess the relative rate of progression of geographic atrophy (GA) based on the hypothesis that noncircular configuration of the atrophic lesion may be a risk factor for enlargement.

DESIGN Cohort study.

PARTICIPANTS Digitized color photographs of 593 eyes with GA from the Age-Related Eye Disease Study (AREDS).

METHODS A novel parameter called the “Geographic Atrophy Circularity Index” (GACI) was developed on the basis of area and perimeter measurements to categorize the irregularity of the shape of GA. The GACI ranges from 0.0 to 1.0 and is categorized into 3 groups: 0.25 (very irregular), 0.25 to <0.75 (partly irregular), and ≥ 0.75 (circular).


RESULTS The mean growth rate in the 3 categories was 0.40 (± 0.18), 0.36 (± 0.30), and 0.21 (± 0.22) mm/year, respectively (P < 0.001). By adjusting for known confounders, baseline area, duration of GA, and configuration, GACI categories were significantly associated with increased growth rate of GA (P < 0.001).

CONCLUSIONS The GACI was associated with the progression rate of GA and may be a useful measure for clinical trial eligibility. The association also suggests that enlargement of GA may be related to the extent of the junctional zone of damaged retinal pigment epithelium, which increases with noncircularity for a given GA area.

Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.