Angiolymphoid hyperplasia with eosinophilia of the orbit and ocular adnexa: report of 5 cases.

Heather Potter // Publications // May 01 2014

PubMed ID: 24676051

Author(s): Azari AA, Kanavi MR, Lucarelli M, Lee V, Lundin AM, Potter HD, Albert DM. Angiolymphoid hyperplasia with eosinophilia of the orbit and ocular adnexa: report of 5 cases. JAMA Ophthalmol. 2014 May;132(5):633-6. doi: 10.1001/jamaophthalmol.2013.8243. Review. PMID 24676051

Journal: Jama Ophthalmology, Volume 132, Issue 5, May 2014

IMPORTANCE To report the clinical and histopathologic findings of ocular adnexal angiolymphoid hyperplasia with eosinophilia, an unusual but often misdiagnosed benign disorder.

OBSERVATIONS The ophthalmologic findings of angiolymphoid hyperplasia with eosinophilia with ocular adnexal involvement are variable and include eyelid swelling, ptosis, proptosis, and loss of vision. Imaging studies typically reveal a well-circumscribed mass in the orbit. The condition may resemble other diseases that involve the orbit and ocular adnexal tissue, such as lymphoma, hemangioma, sarcoidosis, and dermoid cyst. Histopathologic analysis reveals marked vascular proliferation with an accompanying inflammation composed of numerous eosinophils, lymphocytes, and plasma cells.

CONCLUSIONS AND RELEVANCE Angiolymphoid hyperplasia with eosinophilia is a rare disease that can affect the ocular adnexal tissue. The clinical presentation is often nonspecific; therefore, histopathologic studies are essential for diagnosis and subsequent management of this benign condition.