Is renal function associated with early age-related macular degeneration?

Kleins Lab // Publications // Aug 01 2014

PubMed ID: 24879085

Author(s): Chong EW, Guymer RH, Klein R, Klein BE, Cotch MF, Wang JJ, Shlipak MG, Wong TY. Is renal function associated with early age-related macular degeneration? Optom Vis Sci. 2014 Aug;91(8):860-4. doi: 10.1097/OPX.0000000000000288. PMID 24879085

Journal: Optometry And Vision Science : Official Publication Of The American Academy Of Optometry, Volume 91, Issue 8, Aug 2014

PURPOSE Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD.

METHODS A population-based, cross-sectional analysis of persons aged 45 to 84 years was conducted with renal function measured using serum creatinine and cystatin C levels and the estimated glomerular filtration rate (eGFR) calculated. Age-related macular degeneration status was ascertained from retinal photographs.

RESULTS Of 5874 participants, 221 had early AMD. High serum cystatin C and low eGFR (≤60 ml/min/1.73 m) were not associated with early AMD in our multivariate analyses. Among normotensive persons, however, highest versus other deciles of cystatin C were associated with an increased prevalence of early AMD (odds ratio, 1.80; 95% confidence interval, 1.00 to 3.23).

CONCLUSIONS Results could not confirm an association between kidney function and early AMD. The borderline association between cystatin C and early AMD in normotensive persons require further verification.