Author(s): Duke FD, Teixeira LB, Galle LE, Green N, Dubielzig RR. Malignant uveal schwannoma with peripheral nerve extension in a 12-week-old color-dilute Labrador Retriever. Vet Pathol. 2015 Jan;52(1):181-5. doi: 10.1177/0300985814522811. Epub 2014 Feb 10. PMID 24513800
Journal: Veterinary Pathology, Volume 52, Issue 1, Jan 2015
The formalin-fixed, amber-colored right globe from a 12-week-old female silver Labrador Retriever dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin for light microscopic evaluation. The clinical history described a collapsed anterior chamber and multifocal nodular lesions in the peripheral iris. Histologically, immunohistochemically, and ultrastructurally, the uveal mass was consistent with a malignant schwannoma; there was extension along peripheral nerves within the sclera. The signalment and behavior of the neoplasm distinguish it from the uveal schwannoma of blue-eyed dogs and bear some resemblance to the ocular lesions in human neurofibromatosis. The dilute color mutation may contribute to the cause. Six weeks later, the dog did not develop any additional masses.