THE ASSOCIATION BETWEEN CUTICULAR DRUSEN AND KIDNEY FUNCTION: A Population-Based Case-Control Study.

Kleins Lab // Publications // May 01 2016

PubMed ID: 27115854

Author(s): Høeg TB, Klein R, Moldow B, La Cour M, Klemp K, Erngaard D, Buch H, Ellervik C. The association between cuticular drusen and kidney function: A population-based case-control study. Retina. 2016 May;36(5):896-900. doi: 10.1097/IAE.0000000000000808. PMID 27115854

Journal: Retina (Philadelphia, Pa.), Volume 36, Issue 5, May 2016

PURPOSE To determine the association between cuticular drusen (CD) and kidney function.

DESIGN observational case-control study.

METHODS

SETTING Population-based. Patients or Study Population: 53 participants with (CD) and 53 age- and sex-matched controls, selected from the Danish Rural Eye Study. Cuticular drusen participants were diagnosed using fluorescein angiography and controls were excluded if the patients were suspected of having CD on fundus photography or did not have an available estimated glomerular filtration rate.

MAIN OUTCOME MEASURES creatinine and estimated glomerular filtration rate.

RESULTS The mean estimated glomerular filtration rate of those with CD was 73.3 mL·min·1.73 m (95% confidence interval [CI]: 70.0-76.6) and 73.4 mL·minute·1.73 m (95% CI: 69.5-77.3) in controls. The difference was not significant (P: 0.970). The mean creatinine among those with CD was 72.8 μmol/L (69.3-76.4) and 73.5 μmol/L (95% CI: 69.3-77.6) among controls. The difference was not significant (P = 0.820).

CONCLUSION The authors did not find an association between a (CD) diagnosis and decreased kidney function at a population level.