Author(s):Kopplin LJ, Mount G, Suhler EB. Review for disease of the year: epidemiology of HLA-B27 associated ocular disorders. Ocul Immunol Inflamm. 2016 Aug;24(4):470-5. doi: 10.1080/09273948.2016.1175642. Epub 2016 May 27. Review. PMID 27232197
Journal: Ocular Immunology And Inflammation, Volume 24, Issue 4, Aug 2016
Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.