oGVHD

Actively Recruiting // Brandt Lab // Clinical Trials // Cornea // Dry Eye // GVHD // Michele Martin // Jan 28 2019

Scleral Contact Lens Reduction of Dry Eye Inflammation in Patients with Graft-Versus-Host Disease (GVHD)

  • Investigator Initiated
  • Principal Investigator: Curtis Brandt, PhD
  • Clinical Collaborator: Michele Martin, OD
  • Study Coordinator: Kris Dietzman

Study objective:

The use of scleral contact lenses for increased comfort and vision in ocular graft vs host patients with dry eye disease.

Study design:

The study will include three clinic visits over a 3-month period. Visits will consist of an Ocular Surface Disease Index (OSDI) questionnaire, tear film collection, and slit lamp photography in addition to regular clinical activities.

Inclusion criteria:

  • Male or female patients ≥ 18 years of age with confirmed diagnosis of dry eye and GVHD
  • Ability to discontinue topical anti-inflammatory medications for 10 days prior to Visit 1
  • Systemically stable with GVHD under control as determined by referring physician or transplant medicine team
  • Scleral contact lenses prescribed by treating eye doctor as standard-of-care for GVHD associated dry eye

Exclusion criteria:

  • Any active ocular disease other than dry eye
  • Contact lens wear
  • Any ocular surgery in the last 6 months
  • Any topical medicine other than lubricants or tears
  • Systemic anti-inflammatory therapies for at least 3 months before initial sample collection
  • Relapse of malignancy
  • Active infection in any part of the body

Contact Kris Dietzman with questions, 608-263-9035