The Microbiome in Juvenile Idiopathic Arthritis Associated Uveitis

  • Investigator Initiated
  • Principal Investigator: Laura Kopplin, MD, PhD
  • Study Coordinator: Kelly Boyd

Study objective:

To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.

Study design:

The study will comprise three groups: patients with JIA with uveitis, patients with JIA without uveitis and healthy controls. There will be one study visit involving medical history, a food frequency questionnaire, and collection of a stool sample using a provided fecal collection kit. Fecal samples will undergo extraction for DNA/genetic analysis and evaluation of the microbiome composition.

Inclusion criteria:

  • Male or female patients ≥ 2 years of age
  • Diagnosis of JIA arthritis within 1 year of enrollment (for JIA without uveitis patients)
  • Diagnosis of uveitis within 1 year of enrollment (for JIA uveitis patients)

Exclusion criteria:

  • Systemic antibiotic treatment within 3 months
  • Diarrheal illness within 3 months
  • Prior or current treatment with disease modifying anti-rheumatic drugs (DMARDs) or biologic therapy
  • History of prescription dietary supplements (probiotics, prescription formula)

Contact Kelly Boyd with questions, 608-265-4589