Actively Recruiting // Clinical Trials // Juvenile Idiopathic Arthritis // Laura Kopplin // Uveitis // Dec 01 2020
The Microbiome in Juvenile Idiopathic Arthritis Associated Uveitis
Principal Investigator: Laura Kopplin, MD, PhD
Study Coordinator: Kelly Boyd
To compare the gut microbiota composition in pediatric Juvenile Idiopathic Arthritis (JIA) uveitis patients to JIA patients without uveitis and to healthy controls.
The study will comprise three groups: patients with JIA with uveitis, patients with JIA without uveitis and healthy controls. There will be one study visit involving medical history, a food frequency questionnaire, and collection of a stool sample using a provided fecal collection kit. Fecal samples will undergo extraction for DNA/genetic analysis and evaluation of the microbiome composition.
Male or female patients ≥ 2 years of age
Diagnosis of JIA arthritis within 1 year of enrollment (for JIA without uveitis patients)
Diagnosis of uveitis within 1 year of enrollment (for JIA uveitis patients)
Systemic antibiotic treatment within 3 months
Diarrheal illness within 3 months
Prior or current treatment with disease modifying anti-rheumatic drugs (DMARDs) or biologic therapy
History of prescription dietary supplements (probiotics, prescription formula)