PubMed ID: 34709007
Author(s): Schildroth KR, Mititelu M, Etheridge T, Holman I, Chang JS. Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis: Novel Findings and OCT-Angiography Analysis. Retin Cases Brief Rep. 2021 Jan 22. doi: 10.1097/ICB.0000000000001132. [Epub ahead of print] PMID 34709007
Journal: Retinal Cases & Brief Reports, Jan 2021
Purpose To present novel findings in stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR), including the largest series of optical coherence tomography angiography (OCT-A) findings to date.
Methods A retrospective case series with multimodal imaging was obtained and reviewed.
Results All three patients were women, ages 59-63. Two cases were unilateral and one was bilateral. Vision ranged from 20/20 to 20/60 in the affected eyes. Peripheral retinoschisis was observed in all three patients. All patients were followed for a minimum of one year. In one case, progressive macular retinoschisis leading to foveal involvement was observed over two years, with an associated vision decline from 20/25 to 20/60. Attempted interventions included topical dorzolamide in all cases and intravitreal bevacizumab in one patient; however, no treatment effect was observed. Foveal avascular zone (FAZ) size was within normal limits (mean 280[micro]m). In all SNIFR eyes, the retinoschisis cavities were nonvascular.
Conclusion Novel findings regarding SNIFR include the progressive nature of foveal involvement and the lack of response to topical dorzolamide and intravitreal bevacizumab. FAZ was normal in all eyes, consistent with the relatively preserved vision in these cases. Retinoschisis cavities were nonvascular in all eyes, a finding which may give insight into the mechanism of this disease.
(C) 2021 by Ophthalmic Communications Society, Inc.