Genome Sequence of the Virulent Model Herpes Simplex Virus 1 Strain McKrae Demonstrates the Presence of at Least Two Widely Used Variant Strains.

PubMed ID: 33766904

Author(s): Renner DW, Parsons L, Shreve JT, Engel EA, Kuny CV, Enquist L, Neumann D, Mangold C, Szpara ML. Genome sequence of the virulent model herpes simplex virus 1 strain McKrae demonstrates the presence of at least two widely used variant strains. Microbiol Resour Announc. 2021 Mar 25;10(12). pii: e01146-19. doi: 10.1128/MRA.01146-19. PMID 33766904

Journal: Microbiology Resource Announcements, Volume 10, Issue 12, Mar 2021

Herpes simplex virus 1 (HSV-1) strain McKrae was isolated in 1965 and has been utilized by many laboratories. Three HSV-1 strain McKrae stocks have been sequenced previously, revealing discrepancies in key genes. We sequenced the genome of HSV-1 strain McKrae from the laboratory of James M. Hill to better understand the genetic differences between isolates.