Decreased outflow facility and Schlemm’s canal defects in a mouse model of glaucoma.

PubMed ID: 36152913

Author(s): Mavlyutov TA, Kuhn MS, Bilal SE, De Ieso ML, Chauhan AK, Stamer WD, McDowell CM. Decreased outflow facility and Schlemm’s canal defects in a mouse model of glaucoma. Exp Eye Res. 2022 Dec;225:109249. doi: 10.1016/j.exer.2022.109249. Epub 2022 Sep 21. PMID 36152913

Journal: Experimental Eye Research, Volume 225, Dec 2022

Previously we identified B6.EDA+/+ mice as a novel mouse model that presents with elevated IOP and trabecular meshwork damage. Here, we expand on our previous findings by measuring aqueous humor outflow facility and analyzing the integrity of the inner wall of Schlemm’s canal. As expected, intraocular pressure (IOP) was increased, and outflow facility was decreased compared to C57BL/6J controls. B6.EDA+/+ mice had significantly increased expression of the adherens junction protein, VE-cadherin by the inner wall endothelium of Schlemm’s canal. These data suggest that in addition to trabecular meshwork damage, there are changes in Schlemm’s canal in B6.EDA+/+ mice that lead to aqueous outflow dysfunction and ocular hypertension.