PubMed ID: 39433672
Author(s): McDowell CM. The Inducible TGFbeta2 Ocular Hypertension Mouse Model. Methods Mol Biol. 2025;2858:123-129. doi: 10.1007/978-1-0716-4140-8_11. PMID 39433672
Journal: Methods In Molecular Biology (Clifton, N.J.), Volume 2858, 2025
There is a great need for the development of mouse models of ocular hypertension. Here, we describe an inducible mouse model of ocular hypertension that produces a homogeneous intraocular pressure (IOP) response and can be induced in any mouse strain of choice without the need for extensive breeding. The procedure utilizes an ocular hypertension and glaucoma-relevant transgene, bioactivated TGFβ2, and an adenovirus 5 virus with select tropism for the trabecular meshwork (TM).
© 2025. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.