Author(s): Galinos SO, Asdourian GK, Woolf MB, Stevens TS, Lee CB, Goldberg MF, Chow JC, Busse BJ. Spontaneous remodeling of the peripheral retinal vasculature in sickling disorders. Am J Ophthalmol. 1975 May;79(5):853-70. PMID 1146948
Journal: American Journal Of Ophthalmology, Volume 79, Issue 5, May 1975
Periodic photographic and angiographic surveys of patients with the earliest stages of sickle retinopathy showed a number of fundus findings. In seven cases (sickle cell anemia, four; sickle cell hemoglobin C, three), these findings included: (1) a variety of vascular abnormalities in the equatorial and post-equatorial retina such as segmented dilations of the vessel walls, hairpin-shaped vascular loops, hypertrophic, tortuous A-V anastomoses, intraluminal plugs, closure and loss of capillary bed, and terminal budding of capillaries; and (2) a continuous, spontaneous remodeling of the peripheral retinal vasculature due to successive closures and reopenings of equatorial retinal vessels. A centripetal recession of the peripheral retinal vasculature usually resulted. No correlation between the ophthalmoscopic and the systemic condition of the patients could be made.