Toxicity of combined therapy with carbonic anhydrase inhibitors and aspirin.

Kaufman Lab // Publications // Oct 01 1978

PubMed ID: 707596

Author(s): Anderson CJ, Kaufman PL, Sturm RJ. Toxicity of combined therapy with carbonic anhydrase inhibitors and aspirin. Am J Ophthalmol. 1978 Oct;86(4):516-9.

Journal: American Journal Of Ophthalmology, Volume 86, Issue 4, Oct 1978

A 67-year-old woman and a 75-year-old woman taking carbonic anhydrase inhibitors for therapy of glaucoma and high doses of aspirin for therapy of arthritis developed severe acid-base imbalance and salicylate intoxication. Neither patient exhibited ill effects when taking high aspirin doses without carbonic anhydrase inhibitor. Carbonic anhydrose inhibitor-induced acidemia increases the risk of developing salicylate intoxication in patients receiving high aspirin doses.