Author(s): Weichselbaum RR, Zakov ZN, Albert DM, Friedman AH, Nove J, Little JB. New findings in the chromosome 13 long-arm deletion syndrome and retinoblastoma. Ophthalmology. 1979 Jun;86(6):1191-201. PMID 118416
Journal: Ophthalmology, Volume 86, Issue 6, Jun 1979
New clinical and pathologic findings in patients with deletion of the long arm of chromosome 13 (13q-) include optic nerve hypoplasia and retinal dysplasia. Fibroblasts derived from patients with a 13q- syndrome with and without retinoblastoma, as well as from familial and sporadic retinoblastoma, are a useful model for the study of genetic susceptibility to the development of spontaneous and radiation-induced cancers. Fibroblasts from patients with hereditary retinoblastoma appear more radiosensitive than fibroblasts from patients with sporadic retinoblastoma or normal control patients.