Feline uveal melanoma model induced with feline sarcoma virus.

Daniel Albert // Publications // May 01 1981

PubMed ID: 6260703

Author(s): Albert DM, Shadduck JA, Craft JL, Niederkorn JY. Feline uveal melanoma model induced with feline sarcoma virus. Invest Ophthalmol Vis Sci. 1981 May;20(5):606-24. PMID 6260703

Journal: Investigative Ophthalmology & Visual Science, Volume 20, Issue 5, May 1981

This paper described the first animal model of a virally induced uveal melanoma. Tumors developed following the injection of an RNA tumor virus, i.e., Gardner strain feline sarcoma virus, into the anterior chamber of newborn kittens. Histologically, the tumors were found to be iris and ciliary body melanomas, many of which showed invasion. The histology and ultrastructure of those tumors are described.