In vitro malignant transformation of hamster retina by herpes simplex virus.

Publications // Nov 01 1983

PubMed ID: 6315628

Author(s): Albert DM, Papale JJ, Strumph P, Fournier GA. In vitro malignant transformation of hamster retina by herpes simplex virus. Invest Ophthalmol Vis Sci. 1983 Nov;24(11):1489-95.

Journal: Investigative Ophthalmology & Visual Science, Volume 24, Issue 11, Nov 1983

Hamster retina was infected in vitro with irradiated herpes simplex virus type 2. Cells underwent malignant transformation, and when injected subcutaneously into nude mice and hamsters, produced transferable tumors. Transformed cells were found to have HSV antigen as determined by indirect fluorescent staining. In addition, the undifferentiated transformed retinal cells possess neurosecretory granules and retinoic acid receptors and produce growth factor, features similar to those found in spontaneous human retinoblastoma. This is the first neoplasm of ocular tissues induced experimentally by herpes simplex virus (HSV).