Hyperthermic treatment of intraocular tumors.

Daniel Albert // Publications // Oct 01 1984

PubMed ID: 6487114

Author(s): Finger PT, Packer S, Svitra PP, Paglione RW, Chess J, Albert DM. Hyperthermic treatment of intraocular tumors. Arch Ophthalmol. 1984 Oct;102(10):1477-81. PMID 6487114

Journal: Archives Of Ophthalmology (Chicago, Ill. : 1960), Volume 102, Issue 10, Oct 1984

A 5.8-gigahertz (GHz) ophthalmic microwave applicator was used to treat choroidal melanoma (Green strain) in rabbits. High-frequency electromagnetic radiation provides a favorable dose distribution to induce local hyperthermia in the treatment of intraocular tumors. Heating of the neoplasm, while sparing normal ocular structures, is best accomplished by a transscleral approach. A hyperthermia plaque is placed on the sclera at the base of the intraocular tumor. Contact (resistive) heating and electromagnetic radiation (radiofrequency and microwave) are best suited to a plaque technique. The advantages of electromagnetic heat induction, as compared with contact heating, are twofold: the depth of hyperthermic penetration can be modulated by frequency selection, and the tissues with low water content (sclera) remain relatively unaffected by microwaves. The 5.8-GHz ophthalmic microwave applicator satisfies the requirements for local hyperthermic treatment of intraocular tumors.